Language
English
Publication Date
12-1-2025
Journal
Stem Cell Research
DOI
10.1016/j.scr.2025.103862
PMID
41172710
Abstract
Drusen are extracellular deposits between the retinal pigment epithelium and Bruch's membrane, commonly linked to age-related macular degeneration (AMD). However, their presence in younger individuals offers a unique opportunity to study early disease mechanisms before extensive degeneration. We generated two human induced pluripotent stem cell (hiPSC) lines from siblings' peripheral blood mononuclear cells-one with early-onset bilateral drusen and the other unaffected. This genetically matched iPSC pair enables investigation of early drusen associated pathological changes driving retinal disease development.
Keywords
Humans, Induced Pluripotent Stem Cells, Siblings, Retinal Drusen, Male, Macular Degeneration, Female
Published Open-Access
yes
Recommended Citation
Singh, Sonali; Runyon, Wendy; Hu, Sam; et al., "Generation of iPSCs (RFSCi007-A, RFSCi008-a) From a Patient With Early-Onset Bilateral Drusen and a Healthy Sibling for Retinal Disease Modeling" (2025). Faculty and Staff Publications. 5526.
https://digitalcommons.library.tmc.edu/baylor_docs/5526