Language

English

Publication Date

9-1-2025

Journal

Stem Cell Research

DOI

10.1016/j.scr.2025.103768

PMID

40627958

Abstract

Age-related macular degeneration (AMD) has significant genetic component, yet monozygotic twins frequently exhibit discordance in disease status, highlighting the role of non-genetic factors. To enable comparative studies of AMD pathogenesis, we generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of a monozygotic twin pair discordant for AMD. These iPSC lines offer a unique genetically matched resource to investigate molecular differences between affected and unaffected twins, as well as their responses to genetic, epigenetic, and environmental contributors to AMD development.

Keywords

Humans, Induced Pluripotent Stem Cells, Macular Degeneration, Twins, Monozygotic, Cell Line, Male, Female, Leukocytes, Mononuclear

Published Open-Access

yes

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