Language
English
Publication Date
8-1-2025
Journal
Stem Cell Research
DOI
10.1016/j.scr.2025.103715
PMID
40273531
Abstract
Age-related macular degeneration (AMD) is a leading cause of vision loss, driven by retinal pigment epithelium (RPE) and photoreceptor degeneration. A key feature is drusen accumulation between the RPE and Bruch's membrane. In intermediate AMD, hyperreflective foci (HRF)-bright intraretinal lesions visible on optical coherence tomography (OCT) imaging-serve as biomarkers of disease progression. To study HRF mechanisms, we generated induced pluripotent stem cell (iPSC) lines from an AMD patient with HRF overlying drusen (RFSC4) and their unaffected sibling (RFSC3). These iPSC models offer a platform to explore disease mechanisms and develop therapies for AMD.
Keywords
Humans, Induced Pluripotent Stem Cells, Macular Degeneration, Cell Line, Retinal Drusen, Siblings, Tomography, Optical Coherence, Retinal Pigment Epithelium, Male
Published Open-Access
yes
Recommended Citation
Ashrafi, Adnin; Runyon, Wendy; Hu, Sam; et al., "Generation of Human Induced Pluripotent Stem Cell Lines From an Age-Related Macular Degeneration Patient With Hyperreflective Foci Overlying Drusen (RFSCi002-a) and an Unaffected Sibling (RFSCi001-A)" (2025). Faculty and Staff Publications. 5530.
https://digitalcommons.library.tmc.edu/baylor_docs/5530