Pediatric Hepatocellular Adenomas: What Is Known and What Is New?

Authors

Andres F Espinoza
Sanjeev A Vasudevan
Prakash M Masand
Dolores H Lòpez-Terrada
Kalyani R Patel

Language

English

Publication Date

9-29-2023

Journal

Cancers

DOI

10.3390/cancers15194790

PMID

37835484

PMCID

PMC10571754

PubMedCentral® Posted Date

9-29-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Current understanding and classification of pediatric hepatocellular adenomas (HCA) are largely based on adult data. HCAs are rare in children and, unlike in adults, are often seen in the context of syndromes or abnormal background liver. Attempts to apply the adult classification to pediatric tumors have led to several "unclassifiable" lesions. Although typically considered benign, few can show atypical features and those with beta-catenin mutations have a risk for malignant transformation. Small lesions can be monitored while larger (>5.0 cm) lesions are excised due to symptoms or risk of bleeding/rupture, etc. Management depends on gender, age, underlying liver disease, multifocality, size of lesion, histologic subtype and presence of mutation, if any. In this review, we summarize the data on pediatric HCAs and highlight our experience with their diagnosis and management.

Keywords

liver, adenoma, pediatric

Published Open-Access

yes

Recommended Citation

Espinoza, Andres F; Vasudevan, Sanjeev A; Masand, Prakash M; et al., "Pediatric Hepatocellular Adenomas: What Is Known and What Is New?" (2023). Faculty and Staff Publications. 5577.
https://digitalcommons.library.tmc.edu/baylor_docs/5577