Language
English
Publication Date
1-1-2024
Journal
Pediatric and Developmental Pathology
DOI
10.1177/10935266231204788
PMID
37903123
PMCID
PMC11015706
PubMedCentral® Posted Date
10-30-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Hepatoblastomas (HB) are embryonal tumors with quiet genomes diagnosed mostly in children under 3 years of age and often cured by surgical resection and chemotherapy. However, a subset of HBs behave aggressively, displaying characteristic histologic features and higher genomic instability. Hepatocellular neoplasm-not otherwise specified (HCN-NOS) is a provisional diagnostic category for tumors exhibiting either intermediate or a combination of both HB and hepatocellular carcinoma (HCC) histological features. In this study, we characterized an HCN-NOS diagnosed in a 3-year-old patient presenting with a liver mass, in which both HB and HCC histological components were amendable to macro-dissection and molecular profiling. The spectrum of mutations, copy number changes, mRNA, and protein expression profiles within these 2 histologically distinct tumor areas demonstrate molecular heterogeneity and suggest intratumoral clonal evolution of this hepatocellular
Keywords
Child, Preschool, Humans, Carcinoma, Hepatocellular, Hepatoblastoma, Liver Neoplasms, Mutation, Neoplasms, Germ Cell and Embryonal, hepatoblastoma (HB), hepatocellular carcinoma (HCC), hepatocellular neoplasm-not otherwise specified (HCN-NOS), hepatoblastoma with carcinoma features (HBCs), immunohistochemistry (IHC)
Published Open-Access
yes
Recommended Citation
Chen Wongworawat, Yan; Sarabia, Stephen F; Urbicain, Martin; et al., "Molecular Profiling of a Hepatocellular Neoplasm Not Otherwise Specified (HCN-NOS) Demonstrates Distinct Molecular Features in Hepatoblastoma and HCC-Like Components" (2024). Faculty and Staff Publications. 5587.
https://digitalcommons.library.tmc.edu/baylor_docs/5587
Included in
Allergy and Immunology Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Pathology Commons