Monocytic and Blastic Plasmacytoid Dendritic Cell Differentiation in Acute Leukemia With KMT2A Rearrangement

Authors

Owen Xue
Choladda V Curry
Hong Fang
Carlos E Bueso-Ramos
L Jeffrey Medeiros
Wei Wang

Language

English

Publication Date

8-1-2023

Journal

eJHaem

DOI

10.1002/jha2.753

PMID

37601865

PMCID

PMC10435717

PubMedCentral® Posted Date

7-3-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Acute leukemia with KMT2A rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of KMT2A rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both blastic plasmacytoid dendritic cell and monocytic differentiation. This unusual case contributes to the diversity of the immunophenotypic spectrum in KMT2A rearranged acute leukemia and also sheds light on the cell of origin of plasmacytoid dendritic cells.

Keywords

acute leukemia, blastic plasmacytoid dendritic cells, KMT2A rearrangement, monocytic

Published Open-Access

yes

Recommended Citation

Xue, Owen; Curry, Choladda V; Fang, Hong; et al., "Monocytic and Blastic Plasmacytoid Dendritic Cell Differentiation in Acute Leukemia With KMT2A Rearrangement" (2023). Faculty and Staff Publications. 5599.
https://digitalcommons.library.tmc.edu/baylor_docs/5599