The Reprogramming Factor KLF4 in Normal and Malignant Blood Cells

Authors

H Daniel Lacorazza

Publication Date

1-1-2025

Journal

Frontiers in Immunology

DOI

10.3389/fimmu.2025.1584181

PMID

40589762

PMCID

PMC12206627

PubMedCentral® Posted Date

6-16-2023

PubMedCentral® Full Text Version

Post-print

Abstract

The Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger transcription factor that regulates cellular processes in stem cells, epithelial cells, and immune blood cells by controlling gene expression through genetic, epigenetic, and chromatin remodeling. The landmark 2006 publication identified KLF4 as one of the factors involved in reprogramming differentiated cells into pluripotent stem cells, sparking increased interest in KLF4 research a decade after its discovery, particularly in the fields of stem cell research, epithelial cell biology, endothelial cell function, and tumorigenesis. Over the years, KLF4 has emerged as a key transcription factor in modulating innate and adaptive immunity, especially in macrophage differentiation and function. This review summarizes the key findings regarding KLF4 in normal blood cells and leukemia.

Keywords

Humans, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors, Animals, Cellular Reprogramming, Blood Cells, Leukemia, Cell Differentiation, KLF4, hematopoietic stem cells, T cells, leukemia, transcription factor

Published Open-Access

yes

Recommended Citation

H Daniel Lacorazza, "The Reprogramming Factor KLF4 in Normal and Malignant Blood Cells" (2025). Faculty and Staff Publications. 5609.
https://digitalcommons.library.tmc.edu/baylor_docs/5609