Small-Molecule Chemical Probes for the Potential Therapeutic Targets in Alcoholic Liver Diseases

Authors

Ashish Dogra
Feng Li

Language

English

Publication Date

9-1-2023

Journal

Liver Research

DOI

10.1016/j.livres.2023.09.001

PMID

39958379

PMCID

PMC11792063

PubMedCentral® Posted Date

9-12-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Alcoholic liver disease (ALD) encompasses a range of conditions resulting from prolonged and excessive alcohol consumption, causing liver damage such as alcoholic fatty liver, inflammation, fibrosis, and cirrhosis. Alcohol consumption contributes to millions of deaths each year. So far, the effective treatments for ALD are limited. To date, the most effective treatment for ALD is still prevention by avoiding excessive alcohol consumption, and only few specialized medicines are in the market for the treatment of patients suffering from ALD. Small molecules targeting various pathways implicated in ALD pathogenesis can potentially be used for effective therapeutics development. In this review, we provide a concise overview of the latest research findings on potential therapeutic targets, specifically emphasizing small-molecule interventions for the treatment and prevention of ALD.

Keywords

Alcoholic liver disease (ALD), Signaling pathways, Pathogenesis, Therapeutic target chemical probe, Small-molecule probe

Published Open-Access

yes

Recommended Citation

Ashish Dogra and Feng Li, "Small-Molecule Chemical Probes for the Potential Therapeutic Targets in Alcoholic Liver Diseases" (2023). Faculty and Staff Publications. 5622.
https://digitalcommons.library.tmc.edu/baylor_docs/5622