Language

English

Publication Date

7-1-2023

Journal

Biological Research For Nursing

DOI

10.1177/10998004221150395

PMID

36624571

PMCID

PMC10404909

PubMedCentral® Posted Date

1-9-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction with multifaceted pathophysiology. Prior studies have demonstrated higher rates of vitamin D deficiency in individuals with IBS compared to healthy controls (HC), as well as associations of vitamin D concentration with IBS symptoms. A systematic review of 10 mouse and 14 human studies reported a positive association between vitamin D (serum levels and supplementation) and beta diversity of gut microbiome in a variety of conditions. The present retrospective case-control study aimed to compare vitamin D (25(OH)D) plasma concentrations and gut microbiome composition in adult women with IBS (n=99) and HC (n=62). Plasma concentrations of 25(OH)D were assessed using the Endocrine Society Guidelines definition of vitamin D deficiency (25(OH)D < 20 ng/ml) and insufficiency (25(OH)D >20-< 30 ng/ml). 16S rRNA microbiome gene sequencing data was available for 39 HC and 62 participants with IBS. Genus-level Bifidobacterium and Lactobacillus and phylum-level Firmicutes and Bacteroidetes relative abundances were extracted from microbiome profiles. Results showed vitamin D deficiency in 40.3% (n=25) vs. 41.4% (n=41), and insufficiency 33.9% (n=21) vs. 34.3% (n=34) in the HCs vs. IBS groups, respectively. The odds of IBS did not differ depending on 25(OH)D status (p=0.75 for deficient, p=0.78 for insufficient), and the average plasma vitamin D concentration did not differ between IBS (mean 24.8 ng/ml) and HCs (mean 25.1 ng/ml; p=0.57). We did not find evidence of an association between plasma 25(OH)D concentration and richness, Shannon index, Simpson index or specific bacterial abundances in either HCs or the IBS group.

Keywords

Adult, Humans, Female, Animals, Mice, Irritable Bowel Syndrome, Vitamin D, Cross-Sectional Studies, Case-Control Studies, Retrospective Studies, Gastrointestinal Microbiome, RNA, Ribosomal, 16S, Vitamin D Deficiency, irritable bowel syndrome, gastrointestinal microbiome, Vitamin D

Published Open-Access

yes

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