Language

English

Publication Date

4-1-2024

Journal

Expert Review of Proteomics

DOI

10.1080/14789450.2024.2327553

PMID

38536015

PMCID

PMC11426281

PubMedCentral® Posted Date

4-10-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Introduction: Male infertility is a major public health concern globally. Proteomics has revolutionized our comprehension of male fertility by identifying potential infertility biomarkers and reproductive defects. Studies comparing sperm proteome with other male reproductive tissues have the potential to refine fertility diagnostics and guide infertility treatment development.

Areas covered: This review encapsulates literature using proteomic approaches to progress male reproductive biology. Our search methodology included systematic searches of databases such as PubMed, Scopus, and Web of Science for articles up to 2023. Keywords used included 'male fertility proteomics,' 'spermatozoa proteome,' 'testis proteomics,' 'epididymal proteomics,' and 'non-hormonal male contraception.' Inclusion criteria were robust experimental design, significant contributions to male fertility, and novel use of proteomic technologies.

Expert opinion: Expert analysis shows a shift from traditional research to an integrative approach that clarifies male reproductive health's molecular intricacies. A gap exists between proteomic discoveries and clinical application. The expert opinions consolidated here not only navigate the current findings but also chart the future proteomic applications for scientific and clinical breakthroughs. We underscore the need for continued investment in proteomic research - both in the technological and collaborative arenas - to further unravel the secrets of male fertility, which will be central to resolving fertility issues in the coming era.

Keywords

Male, Proteomics, Humans, Infertility, Male, Spermatozoa, Fertility, Proteome, Animals, Biomarkers, Male infertility, sperm proteome, testicular proteomics, epididymal proteomics, proteomic biomarkers, post-translational modifications, male reproductive proteome, fertility diagnostics

Published Open-Access

yes

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