Language
English
Publication Date
3-1-2025
Journal
ACG Case Reports Journal
DOI
10.14309/crj.0000000000001649
PMID
40115891
PMCID
PMC11925415
PubMedCentral® Posted Date
3-20-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Systemic chronic active Epstein-Barr virus (EBV) disease is a rare, delayed, and life-threatening complication of EBV infection. It is characterized by persistent viremia and a mononucleosis-like syndrome with multisystemic involvement because of lymphocytic tissue infiltration. We present the case of an 82-year-old woman without known immunodeficiency who presented with abnormal liver enzymes and interstitial pneumonia. Investigations revealed hyperferritinemia, elevated soluble interleukin-2 receptor levels, hypofibrinogenemia, and hepatosplenomegaly, consistent with hemophagocytic lymphohistiocytosis, as well as a high EBV viral load. Liver biopsy demonstrated portal chronic lymphocytic inflammation and positive EBV in situ hybridization, suggesting systemic chronic active Epstein-Barr virus disease as the underlying etiology.
Keywords
sCAEBV, EBV, HLH, Hepatitis, interstitial pneumonia
Published Open-Access
yes
Recommended Citation
Palomera-Tejeda, Emmanuel; Shaffer, Lauren; Shi, Michael; et al., "Chronic Hepatitis and Hemophagocytic Lymphohistiocytosis Associated With Systemic Chronic Active Epstein-Barr Virus Disease" (2025). Faculty and Staff Publications. 5673.
https://digitalcommons.library.tmc.edu/baylor_docs/5673
Included in
Allergy and Immunology Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Pathology Commons, Pulmonology Commons