Language
English
Publication Date
11-1-2024
Journal
JHLT Open
DOI
10.1016/j.jhlto.2024.100144
PMID
40145064
PMCID
PMC11935423
PubMedCentral® Posted Date
8-8-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Background: Patient-reported outcome measures (PROMs) correlate with heart failure (HF) severity among adults and are adjunct tools in clinical care. Limited data exist regarding the validity of PROMs in pediatric HF. Hypothesis: Patient-Reported Outcome Measurement Information System (PROMIS) Pediatric Fatigue correlates with HF severity, measured by the New York University Pediatric Heart Failure Index (NYU PHFI).
Methods: Children ≥8 and < 18 years old were enrolled prospectively at 4 hospitals, from September 2019 to February 2023, while receiving inpatient HF care. NYU PHFI and pediatric self-report PROMIS measures were administered to inpatient and outpatient patients. PROMIS measures: Mobility, Anxiety, Depressive symptoms, Peer relationships, and Fatigue (primary outcome). Paired t-tests compared PROMIS and NYU PHFI scores across time. A mixed-effects model generated correlation coefficients.
Results: In the 41-patient cohort, 20 (48.8%) were discharged without ventricular assist device/transplant, 18 completed inpatient and outpatient assessments. Mean PROMIS Fatigue t-scores improved: 58.1 ± 12.9 to 48.9 ± 16.9; p = 0.007. Clinically meaningful improvements were observed in other PROMIS t-scores, except Peer relationships. NYU PHFI scores improved: 13.3 ± 2.6 to 7.8 ± 3.4; p < 0.001. PROMIS Fatigue and NYU PHFI moderately correlated (r = 0.5; 95% confidence interval 0.3, 0.6).
Conclusions: PROMIS Fatigue t-scores moderately correlated with HF severity in children suggesting that Fatigue could be useful in longitudinal monitoring and clinical trials.
Keywords
pediatrics, heart failure, patient-reported outcomes, quality of life, PROMIS, PROM
Published Open-Access
yes
Recommended Citation
May, Lindsay J; Stehlik, Josef; Ou, Zhining; et al., "Promis Fatigue Scores Are Moderately Correlated With Heart Failure Severity in Pediatrics" (2024). Faculty and Staff Publications. 5720.
https://digitalcommons.library.tmc.edu/baylor_docs/5720