Language
English
Publication Date
11-1-2025
Journal
JHLT Open
DOI
10.1016/j.jhlto.2025.100393
PMID
41234302
PMCID
PMC12604956
PubMedCentral® Posted Date
9-24-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Heart transplantation is regarded as the definitive treatment for advanced pediatric heart failure. However, concomitant kidney dysfunction often complicates candidate selection for isolated heart transplantation. Prolonged venous congestion, nephrotoxic exposures, and recurrent episodes of acute kidney injury can result in varying degrees of renal impairment. Differentiating between reversible kidney injury secondary to cardiorenal syndrome and irreversible intrinsic renal disease remains a major challenge. Pediatric heart-kidney transplantation has shown survival benefits for patients with end-stage heart failure requiring chronic dialysis, yet its role in patients with less severe renal dysfunction is less clearly defined. This review summarizes the current evidence on patient selection, perioperative and post-transplant management, and ethical considerations for pediatric heart-kidney transplantation.
Keywords
Heart kidney transplantation, Heart transplantation, Simultaneous heart kidney transplantation
Published Open-Access
yes
Recommended Citation
Swati Choudhry, Kriti Puri, and Vikas R Dharnidharka, "Pediatric Heart-Kidney Transplantation" (2025). Faculty and Staff Publications. 5765.
https://digitalcommons.library.tmc.edu/baylor_docs/5765