Language
English
Publication Date
2-1-2023
Journal
Seminars in Liver Disease
DOI
10.1055/s-0042-1759613
PMID
36572031
Abstract
Complications of cirrhotic portal hypertension (PHTN) in children are broad and include clinical manifestations ranging from variceal hemorrhage, hepatic encephalopathy (HE), ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS) to less common conditions such as hepatopulmonary syndrome, portopulmonary hypertension, and cirrhotic cardiomyopathy. The approaches to the diagnosis and management of these complications have become standard of practice in adults with cirrhosis with many guidance statements available. However, there is limited literature on the diagnosis and management of these complications of PHTN in children with much of the current guidance available focused on variceal hemorrhage. The aim of this review is to summarize the current literature in adults who experience these complications of cirrhotic PHTN beyond variceal hemorrhage and present the available literature in children, with a focus on diagnosis, management, and liver transplant decision making in children with cirrhosis who develop ascites, SBP, HRS, HE, and cardiopulmonary complications.
Keywords
Hypertension, Portal, Liver Transplantation, Esophageal and Gastric Varices, Hepatorenal Syndrome, Liver Cirrhosis, Peritonitis, Ascites, Varicose Veins
Published Open-Access
yes
Recommended Citation
Banc-Husu, Anna M; Shiau, Henry; Dike, Peace; et al., "Beyond Varices: Complications of Cirrhotic Portal Hypertension in Pediatrics" (2023). Faculty and Staff Publications. 5807.
https://digitalcommons.library.tmc.edu/baylor_docs/5807
Graphical Abstract