Language

English

Publication Date

1-1-2025

Journal

Journal of Clinical and Experimental Hepatology

DOI

10.1016/j.jceh.2024.102418

PMID

39473447

PMCID

PMC11513801

PubMedCentral® Posted Date

9-25-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Background: Innovative analytic techniques are applied to the psychological functioning of liver transplant (LT) recipients to comprehend its effect on post-transplant survival, hypothesizing that adherence will be predicted by psychosocial functioning.

Methods: The psychosocial functioning of 248 LT recipients (88 females) aged 19 to 74 is assessed using the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT). In addition, the Medication Level Variability Index (MLVI) and biopsy-proven rejection are utilized to evaluate successful adherence. The Z-scores of the SIPAT scores are used to transform them into an ordinal variable with excellent, good, minimally acceptable, and poor categories. We employ a modified version of correspondence analysis to predict the binary MLVI and rejection, which signify either success or failure in adherence, using ordinal MLVI categories as predictors.

Results: The excellent SIPAT category for LT beneficiaries was strongly related to adherence, whereas the minimally acceptable SIPAT was strongly related with failure in adherence. Females, ages 19-50, and ages 67-74 were associated with adherence (r = 0.49-1.00), whereas males and ages 56-60 were associated with failure in adherence (r = 0.43-0.91).

Conclusion: The clinical implications and utility of the novel analytic approaches introduced in the study are discussed.

Keywords

liver transplant (LT) recipients, SIPAT, MLVI, biopsy-proven rejection indicators, correspondence analysis

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.