Language
English
Publication Date
6-14-2023
Journal
Annual Review of Analytical Chemistry
DOI
10.1146/annurev-anchem-061020-015544
PMID
36944233
Abstract
Offering superb speed, chemical specificity, and analytical sensitivity, direct mass spectrometry (MS) technologies are highly amenable for the molecular analysis of complex tissues to aid in disease characterization and help identify new diagnostic, prognostic, and predictive markers. By enabling detection of clinically actionable molecular profiles from tissues and cells, direct MS technologies have the potential to guide treatment decisions and transform sample analysis within clinical workflows. In this review, we highlight recent health-related developments and applications of direct MS technologies that exhibit tangible potential to accelerate clinical research and disease diagnosis, including oncological and neurodegenerative diseases and microbial infections. We focus primarily on applications that employ direct MS technologies for tissue analysis, including MS imaging technologies to map spatial distributions of molecules in situ as well as handheld devices for rapid in vivo and ex vivo tissue analysis.
Keywords
Mass Spectrometry, Medical Oncology, Technology, Workflow, ambient ionization, clinical diagnostics, handheld mass spectrometry–based devices, mass spectrometry imaging
Published Open-Access
yes
Recommended Citation
King, Mary E; Lin, Monica; Spradlin, Meredith; et al., "Advances and Emerging Medical Applications of Direct Mass Spectrometry Technologies for Tissue Analysis" (2023). Faculty, Staff and Students Publications. 6155.
https://digitalcommons.library.tmc.edu/baylor_docs/6155