Language
English
Publication Date
1-1-2024
Journal
Journal of Surgical Case Reports
DOI
10.1093/jscr/rjad739
PMID
38239381
PMCID
PMC10795906
PubMedCentral® Posted Date
1-16-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare spectrum of acute, mucocutaneous drug reactions characterized by epidermal necrosis of the skin and mucous membranes with progressive multiorgan failure. Cutaneous presentation of SJS/TEN is similar to that of acute graft-versus-host disease, creating a diagnostic dilemma in solid-organ transplant recipients presenting with diffuse, erythematous eruptions, skin sloughing, and systemic sequelae, reflective of both diseases. This case report details a 48-year-old woman post-orthotopic liver transplantation (OLT) who developed a diffuse, painful, morbilliform rash with progressive desquamation, along with corresponding pathological analysis indicative of SJS/TEN. There are few documented reports of SJS/TEN in solid-organ transplant recipients, and this case illustrates successful intervention and resolution of SJS/TEN in an OLT recipient while managing intraabdominal sepsis and an episode of acute rejection. Despite its rarity, prompt diagnosis of SJS/TEN and the implementation of tailored therapeutic strategies are crucial in the care of solid-organ transplant recipients.
Keywords
liver transplantation, Stevens–Johnson syndrome, rare diseases, adverse drug reactions
Published Open-Access
yes
Recommended Citation
Huang, Chun-Sing; Strouphauer, Emily; O'Mahony, Christine; et al., "Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in an Orthotopic Liver Transplant Recipient: A Case Report" (2024). Faculty, Staff and Students Publications. 6161.
https://digitalcommons.library.tmc.edu/baylor_docs/6161