Language
English
Publication Date
1-1-2024
Journal
Saudi Journal of Ophthalmology
DOI
10.4103/sjopt.sjopt_256_23
PMID
38628411
PMCID
PMC11017005
PubMedCentral® Posted Date
3-29-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Neuro-ophthalmologic diseases include a broad range of disorders affecting the afferent and efferent visual pathways. Recently, monoclonal antibody (mAb) therapies have emerged as a promising targeted approach in the management of several of these complex conditions. Here, we describe the mechanism-specific applications and advancements in neuro-ophthalmologic mAb therapies. The application of mAbs in neuro-ophthalmologic diseases highlights our increasing understanding of disease-specific mechanisms in autoimmune conditions such as neuromyelitis optica, thyroid eye disease, and myasthenia gravis. Due to the specificity of mAb therapies, applications in neuro-ophthalmologic diseases have yielded exceptional clinical outcomes, including both reduced rate of relapse and progression to disability, visual function preservation, and quality of life improvement. These advancements have not only expanded the range of treatable neuro-ophthalmologic diseases but also reduced adverse events and increased the response rate to treatment. Further research into neuro-ophthalmologic disease mechanisms will provide accurate and specific targeting of important disease mediators through applications of future mAbs. As our understanding of these diseases and the relevant therapeutic targets evolve, we will continue to build on our understanding of how mAbs interfere with disease pathogenesis, and how these changes improve clinical outcomes and quality of life for patients.
Keywords
Biologicals, giant cell arteritis, myasthenia gravis, neuromyelitis optica, thyroid eye disease
Published Open-Access
yes
Recommended Citation
Keehn, Caroline C; Yazdian, Arman; Hunt, Patrick J; et al., "Monoclonal Antibodies in Neuro-Ophthalmology" (2024). Faculty, Staff and Students Publications. 6206.
https://digitalcommons.library.tmc.edu/baylor_docs/6206