Language
English
Publication Date
6-1-2025
Journal
Nature Reviews Immunology
DOI
10.1038/s41577-025-01130-z
PMID
39875604
PMCID
PMC12133415
PubMedCentral® Posted Date
12-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less nucleoprotein assemblies that are termed biomolecular condensates. These condensates are thought to orchestrate fate-determining transcriptional and post-transcriptional processes by locally and transiently concentrating DNA or RNA molecules alongside their regulatory proteins. Findings have established a link between condensate formation and the gene regulatory networks that ensure the proper development of immune cells. Conversely, condensate dysregulation has been linked to impaired immune cell fates, including ageing and malignant transformation. This Review explores the putative mechanistic links between condensate assembly and the gene regulatory frameworks that govern normal and pathological development in the immune system.
Keywords
Humans, Animals, Biomolecular Condensates, Immune System, Cell Differentiation, Gene Expression Regulation, Gene Regulatory Networks
Published Open-Access
yes
Recommended Citation
Kodali, Srikanth; Sands, Caroline M; Guo, Lei; et al., "Biomolecular Condensates in Immune Cell Fate" (2025). Faculty, Staff and Students Publications. 6216.
https://digitalcommons.library.tmc.edu/baylor_docs/6216