Language
English
Publication Date
3-1-2023
Journal
Cancer Medicine
DOI
10.1002/cam4.5409
PMID
36394080
PMCID
PMC10028170
PubMedCentral® Posted Date
11-16-2022
PubMedCentral® Full Text Version
Post-print
Abstract
Background: Immune checkpoint proteins play critical functions during the immune response to cancer and have been targeted by immune checkpoint blockade therapy. V-domain Ig suppressor of T cell activation (VSIR) is one of these immune checkpoint genes and has been investigated extensively in recent years due to its conflicting roles in cancer immunity. Specifically, in acute myeloid leukemia (AML), the prognostic value of VSIR is debated.
Results: In both patient tumor samples and cancer cell lines we find that VSIR has the highest expression in AML out of all cancer types and, in AML, has the highest expression out of all other immune checkpoint genes. Survival analysis indicated that AML patients with higher VSIR expression have significantly shorter survival than those patients with lower expression, even within established AML subgroups (e.g., FAB subtypes). Importantly, VSIR expression is predictive of progression from myelodysplastic syndromes (MDS) patients into AML, suggesting its potential role during the very early stage of AML development and progression. In addition to AML, VSIR also demonstrates prognostic values in other cancer types, including multiple myeloma and mesothelioma.
Conclusion: In summary, our analyses revealed the prognostic value of VSIR and its potential as a target for immunotherapy, especially in AML.
Keywords
Humans, Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, Prognosis, Lymphocyte Activation, AML, MDS, prognosis, VSIR
Published Open-Access
yes
Recommended Citation
Yao, Kevin; Zhou, Emily; Schaafsma, Evelien; et al., "Immune Checkpoint Gene Vsir Predicts Patient Prognosis in Acute Myeloid Leukemia and Myelodysplastic Syndromes" (2023). Faculty, Staff and Students Publications. 6225.
https://digitalcommons.library.tmc.edu/baylor_docs/6225