Language
English
Publication Date
3-1-2024
Journal
Science
DOI
10.1126/science.adk3863
PMID
38422134
PMCID
PMC10921710
PubMedCentral® Posted Date
3-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Endocannabinoid (eCB)-mediated suppression of inhibitory synapses has been hypothesized, but this has not yet been demonstrated to occur in vivo because of the difficulty in tracking eCB dynamics and synaptic plasticity during behavior. In mice navigating a linear track, we observed location-specific eCB signaling in hippocampal CA1 place cells, and this was detected both in the postsynaptic membrane and the presynaptic inhibitory axons. All-optical in vivo investigation of synaptic responses revealed that postsynaptic depolarization was followed by a suppression of inhibitory synaptic potentials. Furthermore, interneuron-specific cannabinoid receptor deletion altered place cell tuning. Therefore, rapid, postsynaptic, activity-dependent eCB signaling modulates inhibitory synapses on a timescale of seconds during behavior.
Keywords
Animals, Mice, Endocannabinoids, Neuronal Plasticity, Synapses, Synaptic Transmission, Calcium Signaling, CA1 Region, Hippocampal, Inhibitory Postsynaptic Potentials, Receptor, Cannabinoid, CB1, Male, Female, Mice, Knockout
Published Open-Access
yes
Recommended Citation
Dudok, Barna; Fan, Linlin Z; Farrell, Jordan S; et al., "Retrograde Endocannabinoid Signaling at Inhibitory Synapses In Vivo" (2024). Faculty, Staff and Students Publications. 6276.
https://digitalcommons.library.tmc.edu/baylor_docs/6276