Language
English
Publication Date
8-1-2025
Journal
Journal of Molecular and Cellular Cardiology
DOI
10.1016/j.yjmcc.2025.06.002
PMID
40499614
PMCID
PMC12809698
PubMedCentral® Posted Date
1-17-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Chronic kidney disease (CKD) is a serious and progressive worldwide health problem affecting 15 % of the global population. CKD is associated with higher mortality rates due to secondary complications such as cardiovascular disease. Common cardiovascular complications found in CKD patients include left ventricular hypertrophy, heart failure, and cardiac arrhythmias. The most common type of cardiac arrhythmia in CKD patients is atrial fibrillation (AF). Proper management of AF is important due to its high risk of cardiovascular complications and stroke. The incidence of AF remains higher in CKD patients than in the healthy population, highlighting the need to improve our understanding of the mechanisms underlying CKD-induced AF. In this review, we discuss well-known systemic factors linking CKD to AF pathogenesis. We highlighted the involvement of several inflammatory mediators in the CKD-induced atrial arrhythmogenesis. We also address special considerations for experimental models of CKD and AF management in CKD patients. Finally, we emphasize the need for a deeper understanding of the molecular underpinning, and for high-quality clinical investigations into the CKD-AF connection.
Keywords
Humans, Atrial Fibrillation, Renal Insufficiency, Chronic, Animals, Atrial fibrillation, calcium signaling, chronic kidney disease, inflammation, oxidative stress
Published Open-Access
yes
Recommended Citation
Navarro-Garcia, Jose Alberto; Keefe, Joshua A; Song, Jia; et al., "Mechanisms Underlying Atrial Fibrillation in Chronic Kidney Disease" (2025). Faculty, Staff and Students Publications. 6299.
https://digitalcommons.library.tmc.edu/baylor_docs/6299
Graphical Abstract