Language
English
Publication Date
9-23-2025
Journal
Trends in Molecular Medicine
DOI
10.1016/j.molmed.2025.08.005
PMID
40993020
Abstract
Oncogenic MYCN drives aggressive disease in many cancers including neuroblastoma (NB). Metabolic reprogramming is essential to support cancer cell homeostasis and survival under nutrient- and oxygen-deprived conditions. MYCN directly reprograms many nodes of tumor-intrinsic metabolism, which have significant repercussions on the cells of the tumor microenvironment (TME), resulting in complex intercellular metabolic circuits that contribute to the immunosuppressive microenvironment of NB. These metabolic circuits are also regulated by the organismal and cellular circadian clock and host diet to further impact the TME and NB oncogenesis. This review discusses the mechanisms by which MYCN regulates the metabolic crosstalk between tumor, TME, and host, and provides evidence that therapeutic targeting of MYCN-reprogrammed metabolism can improve patient outcomes.
Keywords
MYCN, metabolism, neuroblastoma, tumor microenvironment
Published Open-Access
yes
Recommended Citation
Wolf, Amber; Leardini, Davide; Li, Lingzhi; et al., "Deciphering the Mycn-Driven Metabolic Microenvironment of Neuroblastoma" (2025). Faculty, Staff and Students Publications. 6300.
https://digitalcommons.library.tmc.edu/baylor_docs/6300