Language
English
Publication Date
1-1-2024
Journal
Nature Reviews Gastroenterology & Hepatology
DOI
10.1038/s41575-023-00864-2
PMID
38097774
PMCID
PMC12635954
PubMedCentral® Posted Date
11-22-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breastfeeding provide critical sources of early-life microbial and immune training, with important consequences for human health. Only a few studies have directly examined the interactions between the gut microbiome and the immune system during pregnancy, and the subsequent effect on offspring development. In this Review, we aim to describe how the maternal microbiome shapes overall pregnancy-associated maternal, fetal and early neonatal immune systems, focusing on the existing evidence and highlighting current gaps to promote further research.
Keywords
Pregnancy, Female, Infant, Newborn, Humans, Gastrointestinal Microbiome, Immune System, Microbiota, Breast Feeding
Published Open-Access
yes
Recommended Citation
Koren, Omry; Konnikova, Liza; Brodin, Petter; et al., "The Maternal Gut Microbiome in Pregnancy: Implications for the Developing Immune System" (2024). Faculty, Staff and Students Publications. 6341.
https://digitalcommons.library.tmc.edu/baylor_docs/6341