Language
English
Publication Date
1-7-2025
Journal
Cell Metabolism
DOI
10.1016/j.cmet.2024.12.001
PMID
39778518
Abstract
De novo lipogenesis (DNL) is the process whereby cells synthesize fatty acids from acetyl-CoA, contributing to steatosis in fatty liver disease. Two new studies, using genetic mouse models, metabolomics, and pharmacology, identified alternative pathways in DNL and unexpected physiological effects when targeting key enzymes in this pathway.
Keywords
Lipogenesis, Animals, Humans, Mice, Acetyl Coenzyme A, Fatty Acids, Fatty Liver
Published Open-Access
yes
Recommended Citation
Sean M Hartig and Mark A Herman, "Advancing De Novo Lipogenesis: Genetic and Metabolic Insights" (2025). Faculty, Staff and Students Publications. 6398.
https://digitalcommons.library.tmc.edu/baylor_docs/6398