Language
English
Publication Date
7-1-2025
Journal
Clinical Cancer Research
DOI
10.1158/1078-0432.CCR-25-0423
PMID
40327330
PMCID
PMC12213195
PubMedCentral® Posted Date
1-1-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
An increasing number of studies suggest that a significant proportion of children with cancer harbor an underlying predisposition to malignancy, and it is likely that this proportion will only increase. Targeted surveillance for these individuals would likely improve outcomes. Historically, however, for most predisposition syndromes, there were no standardized surveillance protocols for early detection of cancer in predisposed individuals. Therefore, the Pediatric Cancer Working Group of the American Association for Cancer Research convened a workshop in 2016 to develop consensus surveillance recommendations (published in 2017) for children and adolescents with the most common cancer predisposition syndromes. These recommendations provided a consistent approach for pediatric oncologists and other care providers to use as a plan for cancer surveillance in pediatric patients with these syndromes. We held a second workshop in 2023 to update recommendations based upon new data, as well as to add syndromes that were newly described or not addressed in the prior workshop. The resulting articles represent updated surveillance recommendations for currently recognized predisposition syndromes, organized along similar themes. We also address novel approaches to surveillance that are under investigation, as well as prospects for prevention trials for these high-risk populations.
Keywords
Humans, Child, Genetic Predisposition to Disease, Neoplasms, Adolescent, Early Detection of Cancer, Cancer predisposition, genetic susceptibility, cancer surveillance, early tumor detection, cancer genetics
Published Open-Access
yes
Recommended Citation
Brodeur, Garrett M; Diller, Lisa R; Nichols, Kim E; et al., "Pediatric Cancer Predisposition and Surveillance Update: Summary Perspective and Future Directions" (2025). Faculty, Staff and Students Publications. 6400.
https://digitalcommons.library.tmc.edu/baylor_docs/6400