Language
English
Publication Date
11-1-2023
Journal
EJHaem
DOI
10.1002/jha2.783
PMID
38024628
PMCID
PMC10660408
PubMedCentral® Posted Date
9-8-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Pediatric non-Hodgkin lymphoma includes over 30 histologies (many with subtypes), with approximately 800 cases per year in the US, compared to >60,000 cases of adult NHL annually. Improvements in survival in pediatric and adolescent mature B cell NHL over the past 5 decades align with the overall success of the cooperative trial model with dramatic improvements in outcomes through dose escalation of chemotherapy and, more recently, targeted therapy with rituximab. Pediatric dose-intense strategies carry risks of long-term consequences, but treatment failure is nearly universally fatal. By comparison, adult mature B cell lymphoma is typically less aggressive and treated with less intense chemotherapy. Optimizing therapy for adolescents and young adults remains a major challenge that requires creative solutions, including engineering study groups to combine biologically comparable adult and pediatric populations and developing effective salvage strategies that will ultimately be required for investigations of front-line dose reduction. In this review, we discuss challenges and opportunities for improving outcomes for adolescents and young adults with high-grade mature B cell lymphomas, diffuse large B cell lymphoma, and primary mediastinal B cell lymphoma.
Keywords
adolescent, DLBCL, mature B cell lymphoma, PMBCL, young adult
Published Open-Access
yes
Recommended Citation
El-Mallawany, Nader Kim; Giulino-Roth, Lisa; Burke, John M; et al., "Mature B-cell Lymphomas in Adolescents and Young Adults" (2023). Faculty, Staff and Students Publications. 6417.
https://digitalcommons.library.tmc.edu/baylor_docs/6417