Publication Date
8-1-2025
Journal
Advanced Science
DOI
10.1002/advs.202415364
PMID
40411409
PMCID
PMC12376565
PubMedCentral® Posted Date
5-24-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Small alterations during the early stages of the innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes can be engineered to modulate this immune response in beneficial ways. This study presents an innovative patch designed and functionalized to target the innate immunity at the implant site. Mannose moieties are incorporated into collagen patches, resulting in a technology called Local Immunotuning Patch (LIP), designed to directly interact with antigen presenting cells through their mannose receptor. In vitro, LIP shows anti-inflammatory effects on bone marrow-derived macrophages and inhibitory properties even on methicillin-resistant bacterial strains. Subcutaneous implantation in mice reveals that LIP modulates multiple pathways related to innate and adaptive immunity, underscoring its role in shaping an immune-engineered environment around the implant. These findings highlight the potential of this strategy to control the foreign body reaction at the implant site, making it applicable for various uses, including wound healing and surgical infection control in reconstructive procedures.
Keywords
Immunity, Innate, Prostheses and Implants, Animals, Mice, Adaptive Immunity, Foreign-Body Reaction, Wound Healing, Biocompatible Materials, Collagen, Mannose, Tissue Scaffolds, Macrophages, Primary Cell Culture, Mice, Inbred C57BL, Mice, Inbred BALB C, Cross-Linking Reagents
Published Open-Access
yes
Recommended Citation
Taraballi, Francesca; Corbo, Claudia; Enterria-Rosales, Julia; et al., "Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity" (2025). Faculty, Staff and Students Publications. 6443.
https://digitalcommons.library.tmc.edu/baylor_docs/6443