Language
English
Publication Date
11-1-2025
Journal
Pharmacological Research
DOI
10.1016/j.phrs.2025.107995
PMID
41093256
Abstract
Vascular smooth muscle cells (VSMCs) play a pivotal role in maintaining vascular homeostasis and are critical contributors to the pathogenesis of various vascular diseases, including atherosclerosis, calcification, aneurysms, and pulmonary hypertension. Emerging evidence highlights the significance of glucose metabolism in regulating VSMC phenotypic transitions during these pathologies. This review provides a comprehensive overview of the major glucose metabolic pathways in VSMCs, glycolysis, the pentose phosphate pathway (PPP), and the hexosamine biosynthetic pathway (HBP), and their roles in disease development. We summarize the molecular mechanisms linking glucose metabolic reprogramming to VSMC dysfunction, focusing on key regulatory enzymes and signaling pathways. Additionally, we discuss the translational potential of targeting glucose metabolism in VSMCs for therapeutic intervention and the challenges associated with this approach. By underscoring the metabolic shifts underlying VSMC pathophysiology, this review aims to advocate further research into VSMC glucose metabolism as a promising avenue for novel vascular disease treatments.
Keywords
Humans, Animals, Muscle, Smooth, Vascular, Glucose, Myocytes, Smooth Muscle, Vascular Diseases, Glycolysis, Pentose Phosphate Pathway, Aneurysm, Atherosclerosis, Calcification, Glucose Metabolism, Pulmonary Hypertension, Vascular Smooth Muscle cell
Published Open-Access
yes
Recommended Citation
Ma, Qian; Cai, Yongfeng; Yang, Qiuhua; et al., "Reprogrammed Glucose Metabolism in Vascular Smooth Muscle Cells and Its Implications for Vascular Diseases" (2025). Faculty, Staff and Students Publications. 6453.
https://digitalcommons.library.tmc.edu/baylor_docs/6453