Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models

Authors

• Alan Daugherty
• Dianna M Milewicz
• David A Dichek
• Ketan B Ghaghada
• Jay D Humphrey
• Scott A LeMaire
• Yanming Li
• Ziad Mallat
• Yvan Saeys
• Hisashi Sawada
• Ying H Shen
• Toru Suzuki
• Zhen Zhou

Language

English

Publication Date

5-1-2025

Journal

Arteriosclerosis, Thrombosis, and Vascular Biology

DOI

10.1161/ATVBAHA.124.320259

PMID

40079138

PMCID

PMC12018150

PubMedCentral® Posted Date

5-1-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induced by chemical interventions, genetic manipulations, or both. Many parameters should be deliberated in experimental design in concert with multiple considerations when providing dimensional data and characterization of aortic tissues. The purpose of this review is to provide recommendations on guidance in (1) the selection of a mouse model and experimental conditions for the study, (2) parameters for standardizing detection and measurements of aortic diseases, (3) meaningful interpretation of characteristics of diseased aortic tissue, and (4) reporting standards that include rigor and transparency.

Keywords

Animals, Disease Models, Animal, Aorta, Thoracic, Mice, Research Design, Aortic Diseases, Humans, Aortic Aneurysm, Thoracic, aorta, aortopathy, aneurysm, dissection, mouse, thoracic

Published Open-Access

yes

Recommended Citation

Daugherty, Alan; Milewicz, Dianna M; Dichek, David A; et al., "Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models" (2025). Faculty, Staff and Students Publications. 6516.
https://digitalcommons.library.tmc.edu/baylor_docs/6516