Language
English
Publication Date
1-18-2024
Journal
Cell Chemical Biology
DOI
10.1093/nar/gkad522
PMID
37334863
PMCID
PMC10484685
PubMedCentral® Posted Date
6-19-2023
PubMedCentral® Full Text Version
Author MSS
Abstract
RNA secondary structure plays essential roles in encoding RNA regulatory fate and function. Most RNAs populate ensembles of alternatively paired states and are continually unfolded and refolded by cellular processes. Measuring these structural ensembles and their contributions to cellular function has traditionally posed major challenges, but new methods and conceptual frameworks are beginning to fill this void. In this review, we provide a mechanism- and function-centric compendium of the roles of RNA secondary structural ensembles and minority states in regulating the RNA life cycle, from transcription to degradation. We further explore how dysregulation of RNA structural ensembles contributes to human disease and discuss the potential of drugging alternative RNA states to therapeutically modulate RNA activity. The emerging paradigm of RNA structural ensembles as central to RNA function provides a foundation for a deeper understanding of RNA biology and new therapeutic possibilities.
Keywords
Humans, RNA, Protein Structure, Secondary
Published Open-Access
yes
Recommended Citation
Ritwika Bose, Irfana Saleem, and Anthony M Mustoe, "Causes, Functions, and Therapeutic Possibilities of RNA Secondary Structure Ensembles and Alternative States" (2024). Faculty, Staff and Students Publications. 6547.
https://digitalcommons.library.tmc.edu/baylor_docs/6547