Language
English
Publication Date
11-1-2025
Journal
The American Journal of Gastroenterology
DOI
10.14309/ajg.0000000000003383
PMID
40052679
PMCID
PMC12266607
PubMedCentral® Posted Date
3-7-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Introduction: The management of ultrashort (< 1 cm) Barrett's esophagus (BE) remains unclear. We aimed to determine the prevalence of ultrashort BE (USBE) at index diagnosis, identify factors associated with persistent BE after USBE diagnosis, and identify risk of dysplasia after initial USBE in a population of US veterans.
Methods: This was a retrospective cohort study at the Veterans Affairs hospital in Houston, TX, of consecutive patients with new BE diagnosis from November 1990 to June 2022 with follow-up through April 2023. Using a pathology database, we identified patients with a new USBE diagnosis and any subsequent follow-up esophagogastroduodenoscopy (EGD). We examined the association of sociodemographic and clinical risk factors of persistent USBE cohort compared with longer-length segment BE and those with a negative follow-up EGD after index USBE with χ 2 tests and logistic regression models. Last, we calculated the prevalence and incidence of any dysplasia in persistent BE after USBE at index diagnosis compared with BE ≥1 cm. We excluded patients without at least 1 follow-up endoscopy.
Results: Of 739 patients with BE, 167 (22.6%) had USBE on index EGD. Of those with index USBE, 86 (51.5%) had persistent BE and 67 (40.1%) had negative intestinal metaplasia on follow-up EGD. There was a greater proportion of non-Hispanic White and Hispanic than non-Hispanic Black patients with persistent BE after index USBE and the negative follow-up of EGD cohorts ( P = 0.012), but no significant difference in age, sex, smoking status, alcohol status, and body mass index between the 2 groups. White race (adjusted odds ratio [aOR] 3.80; 95% confidence interval [CI] 1.35-10.7) and Hispanic ethnicity (aOR 4.85; 95% CI 1.19-19.7; ref: non-Hispanic Black) were associated with an increased likelihood of persistent BE. During 3,880.7 person-years of follow-up, 112 patients (10 persistent BE after index USBE) developed definite dysplasia/neoplasia. The incidence rate of definite dysplasia/neoplasia was 19.5 per 1,000 person-years (95% CI 10.5-36.3 per 1,000 person-years) in those with persistent BE after USBE and 33.8 per 1,000 person-years (95% CI 27.9-41.1 per 1,000 person-years) in those with longer segment BE ( P value by log-rank test = 0.23; hazard ratio 0.67; 95% CI 0.35-1.29). We did not identify any significant predictors of dysplasia in persistent BE after index endoscopy with USBE.
Discussion: The prevalence of persistent BE after index USBE is high, and there is a risk of developing dysplasia/neoplasia in persistent BE after USBE. We were unable to detect a difference in the risk of dysplasia/neoplasia between persistent BE after index USBE and BE ≥1 cm on index endoscopy in a cohort of US veterans. White race and Hispanic ethnicity are associated with persistent BE after index USBE and may be target demographics for surveillance.
Keywords
Humans, Barrett Esophagus, Male, Female, Retrospective Studies, Middle Aged, Aged, Risk Factors, Prevalence, Endoscopy, Digestive System, Incidence, Texas, Esophageal Neoplasms, Veterans, United States, esophageal adenocarcinoma, dysplasia, incidence, risk factors
Published Open-Access
yes
Recommended Citation
Skef, Wasseem; Haydel, Jasmine; Rao, Ashwin; et al., "High Risk of Persistence and Risk of Dysplasia After Diagnosis of Ultrashort Barrett's Esophagus" (2025). Faculty, Staff and Students Publications. 6619.
https://digitalcommons.library.tmc.edu/baylor_docs/6619