Language
English
Publication Date
1-27-2025
Journal
European Journal of Preventive Cardiology
DOI
10.1093/eurjpc/zwae240
PMID
39041374
Abstract
Recent trends indicate a concerning increase in early-onset atherosclerotic cardiovascular disease (ASCVD) among younger individuals (men aged < 55 years women aged < 65 years). These findings highlight the pathobiology of ASCVD as a disease process that begins early in life and underscores the need for more tailored screening methods and preventive strategies. Increasing attention has been placed on the growing burden of traditional cardiometabolic risk factors in young individuals while also recognizing unique factors that mediate risk of pre-mature atherosclerosis in this demographic such as substance use, socioeconomic disparities, adverse pregnancy outcomes, and chronic inflammatory states that contribute to the increasing incidence of early ASCVD. Additionally, mounting evidence has pointed out significant disparities in the diagnosis and management of early ASCVD and cardiovascular outcomes based on sex and race. Moving towards a more personalized approach, emerging data and technological developments using diverse tools such as polygenic risk scores and coronary artery calcium scans have shown potential in earlier detection of ASCVD risk. Thus, we review current evidence on causal risk factors that drive the increase in early ASCVD and highlight emerging tools to improve ASCVD risk assessment in young individuals.
Keywords
Humans, Atherosclerosis, Risk Assessment, Female, Age of Onset, Male, Incidence, Risk Factors, Prognosis, Middle Aged, Adult, Age Factors, Heart Disease Risk Factors, ASCVD, Epidemiology, Myocardial infarction, Prevention, Risk factors, Young adults
Published Open-Access
yes
Recommended Citation
Mousavi, Idine; Suffredini, John; Virani, Salim S; et al., "Early-Onset Atherosclerotic Cardiovascular Disease" (2025). Faculty, Staff and Students Publications. 6652.
https://digitalcommons.library.tmc.edu/baylor_docs/6652
Graphical Abstract