Language
English
Publication Date
1-1-2026
Journal
International Journal of Biological Sciences
DOI
10.7150/ijbs.123875
PMID
41800249
PMCID
PMC12965075
PubMedCentral® Posted Date
1-30-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial pneumonia of unknown etiology. Its pathogenesis involves complex multicellular interactions and signaling pathways, with fibroblast-to-myofibroblast transition (FMT) being critical for fibrogenesis. Although the transcription factor Y-box binding protein 1 (YBX1) regulates processes such as cell proliferation, transcription, translation, and DNA repair, its role in IPF remains undefined. Here, we demonstrate that YBX1 overexpression significantly promotes transforming growth factor-β1 (TGF-β1)-induced pulmonary FMT, leading to substantially increased extracellular matrix (ECM) deposition in primary human (PHLFs) and mouse (PMLFs) lung fibroblasts. Conversely, YBX1 inhibition markedly suppresses TGF-β1-driven aberrant fibroblast migration and activation. Mechanistically, YBX1 interacts with polypyrimidine tract-binding protein 1 (PTBP1) and binds to the protein tyrosine phosphatase nonreceptor type 1 (PTPN1) promoter to transcriptionally regulate PTPN1, thereby driving FMT.
Keywords
Animals, Humans, Y-Box-Binding Protein 1, Mice, Fibroblasts, Lung, Idiopathic Pulmonary Fibrosis, Bleomycin, Transforming Growth Factor beta1, Mice, Inbred C57BL, Transcription Factors, YBX1, YBX1-PTBP1 interaction, PTPN1, fibroblast activation
Published Open-Access
yes
Recommended Citation
Liu, Huibing; Xia, Cong; Zhang, Yingying; et al., "PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung" (2026). Faculty, Staff and Students Publications. 6778.
https://digitalcommons.library.tmc.edu/baylor_docs/6778