Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation

Authors

Shijie Liu
Vaibhav Deshmukh
Fangfei Wang
Jie Liang
Jenna Cusick
Xiao Li
James F Martin

Publication Date

6-1-2024

Journal

Basic to Translational Science

DOI

10.1016/j.jacbts.2024.02.014

PMID

39070274

PMCID

PMC11282883

PubMedCentral® Posted Date

5-15-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

no

Abstract

Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level. Identifying heart cell proteomes and their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked protein synthesis after myocardial infarction. Our results showed that myocardial infarction suppresses protein synthesis and unveils a decoupling of translation and transcription regulation in cardiomyocytes.

Comments

See editorial "Turn(over) the Page" on page 808.

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