Mindful Diagnostics in Culture-Negative Endocarditis: Early Noninvasive Diagnosis of Tropheryma whipplei by Plasma Microbial Cell-Free DNA

Authors

• Ashita Jain
• Sarwat Khalil
• Muhammad R Sohail
• Laura C Lelenwa
• Enrique Garcia-Sayan
• Kenneth K Liao
• Ahmed Hamdi
• Todd Lasco
• Mayar Al Mohajer

Publication Date

1-1-2026

Journal

Antimicrobial Stewardship & Healthcare Epidemiology

DOI

10.1017/ash.2026.10416

PMID

42318028

PMCID

PMC13273153

PubMedCentral® Posted Date

6-16-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Tropheryma whipplei was identified by plasma microbial cell-free DNA sequencing within 4 days in severe culture-negative endocarditis after antibiotics had already been started. The result supported earlier diagnostic clarification and antimicrobial de-escalation before valve pathology was available, illustrating a practical diagnostic-stewardship role for noninvasive sequencing in high-acuity endocarditis.

Published Open-Access

yes

Recommended Citation

Jain, Ashita; Khalil, Sarwat; Sohail, Muhammad R; et al., "Mindful Diagnostics in Culture-Negative Endocarditis: Early Noninvasive Diagnosis of Tropheryma whipplei by Plasma Microbial Cell-Free DNA" (2026). Faculty, Staff and Students Publications. 6856.
https://digitalcommons.library.tmc.edu/baylor_docs/6856