Dynamics of Gametes and Embryos in the Oviduct: What Can In Vivo Imaging Reveal?

Authors

Shang Wang
Irina V Larina

Publication Date

2-1-2023

Journal

Reproduction

DOI

10.1530/REP-22-0250

PMID

36318634

PMCID

PMC9827618

PubMedCentral® Posted Date

2-1-2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Pregnancy, Humans, Female, Animals, Mice, Fallopian Tubes, Oviducts, Germ Cells, Reproduction, Diagnostic Imaging, Oviduct, gamete, preimplantation embryo, in vivo imaging, mouse

Abstract

IN BRIEF: In vivo imaging of gametes and embryos in the oviduct enables new studies of the native processes that lead to fertilization and pregnancy. This review article discusses recent advancements in the in vivo imaging methods and insights which contribute to understanding the oviductal function.

ABSTRACT: Understanding the physiological dynamics of gametes and embryos in the fallopian tube (oviduct) has significant implications for managing reproductive disorders and improving assisted reproductive technologies. Recent advancements in imaging of the mouse oviduct in vivo uncovered fascinating dynamics of gametes and embryos in their native states. These new imaging approaches and observations are bringing exciting momentum to uncover the otherwise-hidden processes orchestrating fertilization and pregnancy. For mechanistic investigations, in vivo imaging in genetic mouse models enables dynamic phenotyping of gene functions in the reproductive process. Here, we review these imaging methods, discuss insights recently revealed by in vivo imaging, and comment on emerging directions, aiming to stimulate new in vivo studies of reproductive dynamics.