Language

English

Publication Date

6-3-2025

Journal

European Journal of Cardio-Thoracic Surgery

DOI

10.1093/ejcts/ezaf179

PMID

40411760

Abstract

Objectives: This review article aims to examine the surgical approach to patients with failed mitral transcatheter edge-to-edge repair (M-TEER), focusing on operative challenges, decision-making and contemporary outcome data. Technical considerations, including device removal and the management of complex mitral valve (MV) anatomy, are discussed.

Methods: We performed a comprehensive literature review and gathered the experience from high-volume centres in the surgical management of failed M-TEER.

Results: MV surgery after failed M-TEER is a complex but increasingly necessary procedure as the use of M-TEER grows. It occurs in up to 6% of patients, with a median age of 70-76 years at the moment of failure and a median time to failure of < 6 months. MV surgery following M-TEER is associated with high mortality and morbidity, with a reported 30-day mortality ranging from 10% to 40% and 1-year survival below 60%. Functional device failure, structural device failure, MV disease progression and infective endocarditis are frequent mechanisms of M-TEER failure. Surgical MV repair is the preferred management strategy; however, due to the technical and anatomical complexity, MV replacement is performed much more frequently (MV repair rates < 10%).

Conclusions: MV surgery after failed M-TEER poses technical challenges due to the presence of altered anatomy, the need for concomitant procedures and the patient's comorbidities. While surgical intervention carries increased risks, it remains the definitive treatment for failed M-TEER, offering durable relief from MR. Due to the technical complexities associated with these procedures, strong consideration should be given to transferring patients requiring MV surgery after failed M-TEER to high-volume MV centres.

Keywords

Humans, Mitral Valve Insufficiency, Mitral Valve, Heart Valve Prosthesis Implantation, Treatment Failure, Reoperation, Cardiac Catheterization, Aged, Treatment Outcome, Mitral regurgitation, Mitral transcatheter edge-to-edge repair, Mitral valve repair, Mitral valve replacement

Published Open-Access

yes

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