Language

English

Publication Date

1-28-2026

Journal

The Journal of Physiology

DOI

10.1113/JP290180

PMID

41605640

PMCID

PMC12883149

PubMedCentral® Posted Date

2-9-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Cardiovascular diseases remain the leading cause of mortality worldwide, driven by complex, multi-scale mechanisms that span molecular, cellular, and organ-level dysfunction. Effective therapeutic strategies therefore require integrative approaches that link fundamental biology to translational applications. The 8th UC Davis CardioVascular Symposium gathered experts in ion channel biophysics, Ca2+ signaling, arrhythmia mechanisms, and cardiovascular physiology to discuss recent advances and define emerging priorities. This white paper synthesizes the key themes and consensus points that emerged, highlighting progress in two core domains: (1) advances in cardiovascular electrophysiology and arrhythmia mechanisms, and (2) spatiotemporal dynamics of Ca2+ signaling in cardiac and vascular function and remodeling. We also identify conceptual and technical challenges that must be addressed to accelerate therapeutic discovery and emphasize cross-cutting opportunities where experimental and computational approaches can converge. By integrating ion channel biology and Ca2+ signaling mechanisms across scales, this work outlines new directions for advancing cardiovascular research and treatment.

Keywords

cardiovascular disease, ion channels, calcium signaling, calcium dynamics, arrhythmia

Published Open-Access

yes

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