Language
English
Publication Date
4-1-2024
Journal
The Journal of Thoracic and Cardiovascular Surgery
DOI
10.1016/j.jtcvs.2023.10.048
PMID
37913838
Abstract
Background: In pediatrics, implantable continuous-flow ventricular assist devices (IC-VAD) are often used as a "temporary" support, bridging children to cardiac transplantation during the same hospital admission.
Methods: We conducted a retrospective review of our consecutive patients undergoing IC-VAD support at a tertiary pediatric heart center between 2008 and 2022.
Results: We identified 100 IC-VAD implant encounters: HeartWare HVAD (67; 67%), HeartMate II (17; 17%), and HeartMate 3 (16; 16%). The median (range) age, weight, and body surface area at implantation were 14.1 (3.0-56.5) years, 54.8 (13.3-140) kg, and 1.6 (0.6-2.6) m2, respectively. Cardiomyopathy (58; 58%) was the most common etiology, followed by congenital heart disease (37; 37%, including 13 single ventricle). At 6 months of IC-VAD support, 94 (94%) encounters achieved positive outcomes: ongoing support (59; 59%), transplant (33; 33%), and cardiac recovery (2; 2%). Eighty-two encounters (82%) resulted in home discharge with ongoing VAD support, including 38 (46%, out of 82) requiring readmission and 7 (9%, out of 82) resulting in death. There was a clinically significant decrease in morbidity rates before versus after home discharge: bleeding (1.55 vs 0.06), infection (0.84 vs 0.37), and stroke (0.84 vs 0.15 event per patient-year). Overall, 86 encounters (86%) reached positive end points at the latest follow-up (64 transplant, 15 ongoing support, and 7 recovery). Infection (29%; 4 of 14) was the most common cause of negative outcomes, followed by cerebrovascular accident (21%; 3), and unresolved frailty (21%; 3). The estimated overall survival at 1, 2, and 5 years was 90%, 86%, and 77%, respectively.
Conclusions: This study suggests the feasibility of outpatient management of pediatric IC-VAD support. The ability to offer true long-term support maximizes the potential of IC-VAD support, not limited to a temporary bridging tool for heart transplantation.
Keywords
Child, Humans, Adolescent, Young Adult, Adult, Middle Aged, Heart Failure, Heart-Assist Devices, Treatment Outcome, Heart Transplantation, Heart Defects, Congenital, Retrospective Studies, Stroke, congenital heart disease, mechanical circulatory support, pediatric heart failure, ventricular assist device
Published Open-Access
yes
Recommended Citation
Cho, Junsang; Tunuguntla, Hari P; Tume, Sebastian C; et al., "Long-Term Implantable Ventricular Assist Device Support in Children" (2024). Faculty, Staff and Students Publications. 6892.
https://digitalcommons.library.tmc.edu/baylor_docs/6892