Language
English
Publication Date
5-1-2026
Journal
Journal of the Pediatric Orthopaedic Society of North America
DOI
10.1016/j.jposna.2026.100350
PMID
42005368
PMCID
PMC13091138
PubMedCentral® Posted Date
3-6-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Background: Pediatric spinal fusion can result in substantial blood loss, particularly in patients with scoliosis related to underlying neuromuscular (NM) disease. Transfusion is frequently required but carries risks including transfusion reactions, alloimmunization, volume overload, and infection.
Local problem: The American College of Surgeons National Surgical Quality Improvement Program-Pediatrics (ACS NSQIP-P) is a nationally validated, risk-adjusted national outcomes registry. At our institution, ACS NSQIP-P data identified our institution as a high outlier in transfusion for neuromuscular scoliosis patients.
Methods: A multidisciplinary group convened from January 2024 to June 2024 to design and implement a perioperative pathway with the primary goal of reducing transfusion volume to < 25 mL/kg and the secondary goal of reducing overall transfusion volume. The final pathway was formally launched in September 2024.
Interventions: The pathway standardized care across all phases of surgery: preoperative optimization through multidisciplinary review and dedicated clinic visits; intraoperative blood conservation with tranexamic acid, controlled hypotension, cell salvage, standardized lab monitoring, and transfusion thresholds; and postoperative protocols limiting red blood cell transfusion and establishing pediatric intensive care unit guidelines. All departments received targeted education and outcomes were monitored with NSQIP-P data.
Results: In the baseline period of July 2023 to December 2023 (n = 13), the median transfusion volume was 9.3 mL/kg, with 6 patients (46%) exceeding 25 mL/kg (median excess transfusion = 25.8 mL/kg). When the team began meeting between January 2024 and June 2024 (n = 13), the median transfusion volume was 14.4 mL/kg, with 2 patients (15%) exceeding 25 mL/kg (median excess transfusion = 11.4 mL/kg). In the subsequent period, July 2024 to December 2024 (n = 19), the median transfusion volume decreased to 5.1 mL/kg, with 2 patients (11%) exceeding 25 mL/kg (median excess transfusion = 4.6 mL/kg). In the most recent period of January 2025 to June 2025 (n = 13), the median transfusion volume was 7.5 mL/kg with 2 patients (15%) exceeding 25 mL/kg (median excess transfusion = 3.7 mL/kg). At the end of the study interval, our institution was no longer identified as an NSQIP-P outlier and was performing "as expected" in this category.
Conclusions: Implementation of a multidisciplinary, evidence-based, perioperative pathway that includes patient optimization before surgery, balanced transfusions intraoperatively, correction of coagulopathy, and a lower transfusion target of 7 g/dL in stable patients postoperatively, can safely reduce transfusion exposure after NM spinal fusion.
Key concepts: (1)Excessive blood transfusion in neuromuscular spinal fusion is common and associated with adverse outcomes, including infection, transfusion reactions, volume overload, and increased health care costs.(2)The American College of Surgeons National Surgical Quality Improvement Program-Pediatrics is a validated outcomes registry that enables institutions to benchmark performance against others.(3)Implementation of a multidisciplinary, perioperative quality improvement pathway spanning preoperative, intraoperative, and postoperative phases, reduced transfusion requirements in neuromuscular patients undergoing spinal fusion at our institution.
Keywords
NSQIP-P, Quality improvement, Neuromuscular spinal fusion, Neuromuscular, Pediatric spine
Published Open-Access
yes
Recommended Citation
Archer, Holden; Pinto, Venessa L; Russell, Farrah; et al., "Reducing Transfusions in Neuromuscular Spinal Fusion: A National Surgical Quality Improvement Program-Pediatrics Quality Improvement Project" (2026). Faculty, Staff and Students Publications. 6894.
https://digitalcommons.library.tmc.edu/baylor_docs/6894