Language
English
Publication Date
5-1-2026
Journal
Trends Endocrinol Metabolism
DOI
10.1016/j.tem.2025.07.002
PMID
40753007
PMCID
PMC12720270
PubMedCentral® Posted Date
4-28-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
The digestive system is essential for nutrient absorption, processing, and waste elimination. The expression of many genes and physiological processes within this system exhibits a 24-h rhythmicity. However, modern lifestyle factors, such as jet lag, shift work, and irregular eating patterns, significantly disrupt these rhythms, triggering various stress responses and contributing to numerous digestive disorders. Here, we focus on emerging studies on noncanonical clock regulators involved in stress responses, integrate these novel findings into the established model of the core circadian clock, and highlight recent advances in the development of novel therapeutics targeting these 24-h regulators. In addition, we discuss the optimized timing of dietary interventions and drug administration, collectively known as chronotherapy, as a promising approach for managing digestive diseases.
Keywords
Humans, Circadian Clocks, Animals, Stress, Physiological, Circadian Rhythm, Digestive System Diseases, circadian rhythm, stress response, digestive diseases, liver, gut, pancreas
Published Open-Access
yes
Recommended Citation
Zhou, Dishu; López-Valiente, Roberto E; Mattar, Samer G; et al., "Noncanonical Clock Regulators Control Stress Responses in Digestive Diseases" (2026). Faculty, Staff and Students Publications. 6922.
https://digitalcommons.library.tmc.edu/baylor_docs/6922