Heterogeneity and Plasticity of the Naive CD4+ T Cell Compartment

Authors

• Alia Sajani
• Evelien Schaafsma
• Walburga Croteau
• Mohamed ElTanbouly
• Elizabeth C Nowak
• Chao Cheng
• Christopher M Burns
• Mary Jo Turk
• Randolph J Noelle
• J Louise Lines

Language

English

Publication Date

3-24-2026

Journal

Cell Reports

DOI

10.1016/j.celrep.2026.116980

PMID

41719121

Abstract

This study describes the transcriptional heterogeneity of murine and human naive CD4+ T cells as comprising multiple discrete clusters that impact CD4+ T cell fate and trajectories. Naive CD4+ T cells experiencing inflammatory environments exhibit an altered transcriptional state that biases their differentiation trajectories.

Keywords

Animals, CD4-Positive T-Lymphocytes, Humans, Mice, Cell Differentiation, Cell Plasticity, Mice, Inbred C57BL, CP: immunology, IFN, naive T cell heterogeneity, scRNA-seq, tonic signaling

Published Open-Access

yes

Recommended Citation

Sajani, Alia; Schaafsma, Evelien; Croteau, Walburga; et al., "Heterogeneity and Plasticity of the Naive CD4+ T Cell Compartment" (2026). Faculty, Staff and Students Publications. 6938.
https://digitalcommons.library.tmc.edu/baylor_docs/6938