Publication Date
6-1-2025
Journal
Cancer Biomarkers
DOI
10.1177/18758592251344936
PMID
40485257
PMCID
PMC12288413
PubMedCentral® Posted Date
6-9-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Background
Multiple myeloma (MM) is virtually always preceded by monoclonal gammopathy of undetermined significance (MGUS). Elevated serum markers are used to classify MGUS patients into clinical risk categories. Previous research has indicated that the absence of a normal plasma cell signature in MGUS is linked to early progression.
Objective
To confirm that the presence of a “polyclonal plasma cell (PolyPC) signature” serves as a robust negative predictor of MGUS progression.
Methods
374 MGUS patients were enrolled, including 334 patients with stable disease and 40 patients who progressed to MM within 10 years. An oligonucleotide microarray analysis was performed on mRNA extracted from CD138-selected bone marrow plasma cells to evaluate gene expression profiles. The PolyPC signature was developed and validated to assess its role in predicting disease progression. Statistical analyses included Cox proportional hazards models to evaluate progression risk and receiver operating characteristic (ROC) curve analysis to determine the sensitivity, specificity, and overall predictive performance of the PolyPC score.
Results
Through this retrospective study, we developed PolyPC signature based on gene expression profiles of normal, uninvolved plasma cells to predict MGUS progression risk. ROC analysis demonstrated that this signature accurately predicted the risk of MGUS progression (C-statistic: 0.792). A PolyPC score ≤ 11.6 identified a subset of 89 patients with a 10-year progression probability of 31.5% (28/89), while the remaining 285 patients had a progression probability of only 4.2% (12/285) (p < 0.01). Sensitivity and specificity were 70% (28/40) and 81.7% (273/334). The external validation using the SWOG-S0120 dataset reinforces the robustness and clinical applicability of the PolyPC score in predicting MGUS progression to MM.
Conclusions
The strength of the PolyPC signature is a powerful negative predictor of MGUS progression. These findings support incorporating PolyPC into MGUS management to identify patients needing more frequent and intensive monitoring.
Keywords
Humans, Multiple Myeloma, Disease Progression, Monoclonal Gammopathy of Undetermined Significance, Plasma Cells, Male, Female, Aged, Middle Aged, Prognosis, Gene Expression Profiling, Retrospective Studies, Biomarkers, Tumor, Aged, 80 and over, ROC Curve, Transcriptome, Adult, multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), polyclonal plasma cell (PolyPC), gene expression profiling, progression prediction
Published Open-Access
yes
Recommended Citation
Sun, Fumou; Cheng, Yan; Ma, Catherine; et al., "Polyclonal Plasma Cell (PolyPC) Signature as a Key Indicator for Predicting the Progression of Mgus to Multiple Myeloma" (2025). Faculty, Staff and Students Publications. 6945.
https://digitalcommons.library.tmc.edu/baylor_docs/6945