Language
English
Publication Date
1-1-2026
Journal
Clinical and Experimental Gastroenterology
DOI
10.2147/CEG.S495588
PMID
41531650
PMCID
PMC12983157
PubMedCentral® Posted Date
1-7-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Helicobacter pylori (H. pylori) is a human bacterial pathogen that causes one of the most common chronic bacterial infections worldwide. The microorganism has been classified by the International Agency for Research on Cancer as a Group I carcinogen. While the etiological link to gastric cancer is well established, the precise molecular and cellular mechanisms driving this transformation are highly complex and incompletely understood. Fundamentally, the infection results from the chronic presence of acute on chronic gastric mucosal inflammation. H. pylori pathogenicity is increased by bacterial virulence factors including the cytotoxin-associated gene A (CagA) and Vacuolating cytotoxin A (VacA) which may interfere with the host’s cell communication and create a pro-tumorigenic microenvironment. Host microRNAs (miRNAs) may amplify these effects by modulating immune responses, enhancing oncogenic signalling. Despite the proven benefits of H. pylori eradication in reducing cancer risk, especially in high-incidence regions, rising antibiotic resistance and host-related variables impede its global implementation. Recent advances in genomics and multi-omics profiling potentially offer new opportunities for targeted prevention. Moreover, emerging evidence suggests H. pylori may also negatively influence immunotherapy outcomes, underscoring its broader relevance in cancer treatment planning. By synthesizing molecular insights, epidemiological trends, and clinical data, this narrative review examines the multifaceted pathways through which H. pylori contributes to gastric carcinogenesis, integrating current knowledge on microbial virulence, host signalling disruption, immune modulation, and epigenetic remodelling.
Keywords
Helicobacter pylori, gastric cancer, pathogenesis, CagA, VacA, virulence
Published Open-Access
yes
Recommended Citation
Merola, Elettra; Pes, Giovanni Mario; Graham, David Yates; et al., "Helicobacter pylori and Cancer: What's the Link?" (2026). Faculty, Staff and Students Publications. 6995.
https://digitalcommons.library.tmc.edu/baylor_docs/6995