Language
English
Publication Date
12-31-2026
Journal
Oncoimmunology
DOI
10.1080/2162402X.2026.2640261
PMID
41772940
PMCID
PMC12959200
PubMedCentral® Posted Date
3-2-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Steroid receptor coactivator 3 (SRC-3) is highly expressed in regulatory T cells (Tregs) and is important for their immunosuppressive activity. Recently, we demonstrated that disrupting SRC-3 expression in Tregs eliminates triple-negative breast cancer (TNBC) and prostate cancer in syngeneic animal models by generating an anti-tumor immune microenvironment without inducing immune-related adverse events (irAEs). Further analysis of these mice revealed that SRC-3 knockout (KO) Tregs infiltrated breast tumors and facilitated the infiltration of CD8
Keywords
Animals, T-Lymphocytes, Regulatory, Mice, Nuclear Receptor Coactivator 3, Mice, Knockout, Female, Disease Models, Animal, Tumor Microenvironment, Cell Line, Tumor, Humans, Mice, Inbred C57BL, Male, Lymphocytes, Tumor-Infiltrating, Regulatory T cells, steroid receptor coactivator 3, syngeneic murine cancer models, lung cancer, glioblastoma, melanoma
Published Open-Access
yes
Recommended Citation
Sung, Nuri; Kim, Eunsu; Gilad, Yosef; et al., "Steroid Receptor Coactivator 3-Deficient Regulatory T Cells Eradicate Multiple Solid Tumors in Syngeneic Mouse Models" (2026). Faculty, Staff and Students Publications. 7052.
https://digitalcommons.library.tmc.edu/baylor_docs/7052