Language

English

Publication Date

2-19-2026

Journal

Molecular Cell

DOI

10.1016/j.molcel.2026.01.023

PMID

41653922

PMCID

PMC13034722

PubMedCentral® Posted Date

3-31-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

The prevalence of neurodevelopmental disorders (NDDs) in children is increasing, yet their underlying causes remain largely unknown. We identified heterozygous mutations in the Polycomb repressive complex 1 (PRC1) E3 ligases RING1 and RNF2 in individuals with NDDs and revealed distinct mechanisms by which they compromise PRC1 activity. We developed cellular and mouse models carrying the Ring1b

Keywords

Animals, Humans, Polycomb Repressive Complex 1, Ubiquitin-Protein Ligases, Neurodevelopmental Disorders, Chromatin, Mice, Neurogenesis, Polycomb Repressive Complex 2, Male, Epigenesis, Genetic, Mutation, Female, Polycomb-Group Proteins, Neurons, Wnt Signaling Pathway, Protein Binding, Disease Models, Animal, Hippocampus

Published Open-Access

yes

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