Language
English
Publication Date
11-1-2025
Journal
Endocrine Connections
DOI
10.1530/EC-25-0631
PMID
41128555
PMCID
PMC12599134
PubMedCentral® Posted Date
11-6-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Steroid receptor coactivators (SRCs) are master regulators of nuclear receptor signaling and play essential roles in female reproductive physiology. By integrating steroid hormone signaling with growth factors and metabolic pathways, SRC-1, SRC-2, and SRC-3 coordinate key processes such as decidualization, placental development, and ovarian function. Dysregulation of SRCs is strongly linked to the progression of benign gynecologic disorders, including polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids, largely through enhancing hormonal hypersensitivity and disrupting nuclear receptor-mediated cellular pathways. Emerging evidence further implicates specific SRC isoforms in disease pathogenesis, underscoring their potential as biomarkers and therapeutic targets. To inhibit SRC activity, natural compounds (e.g., gossypol, bufalin, verrucarin A) and synthetic small molecules (e.g., SI-2, SI-12, MCB-613) have been developed, demonstrating preclinical efficacy across several human diseases. However, their application in benign reproductive disorders remains largely unexplored. This review summarizes current knowledge of SRC biology in benign gynecologic disorders, outlines their mechanistic roles in disease progression, and highlights opportunities for clinical translation. Targeting SRCs may ultimately represent a novel, nonhormonal, fertility-preserving therapeutic strategy in women's health.
Keywords
SRC, endometriosis, PCOS, leiomyoma
Published Open-Access
yes
Recommended Citation
Park, Yuri; Jeong, Jaeyeong; Kim, Eunsu; et al., "Targeting Steroid Receptor Coactivators for the Treatment of Benign Female Reproductive Disorders" (2025). Faculty, Staff and Students Publications. 7060.
https://digitalcommons.library.tmc.edu/baylor_docs/7060