Publication Date
4-1-2024
Journal
Cold Spring Harbor Perspectives in Biology
DOI
10.1101/cshperspect.a041329
PMID
38052483
PMCID
PMC10982691
PubMedCentral® Posted Date
4-14-2024
PubMedCentral® Full Text Version
Post-print
Abstract
In 2016, a group of researchers engaged in the development of patient-derived xenografts (PDXs) of human breast cancer provided a comprehensive review of the state of the field. In that review, they summarized the clinical problem that PDXs might address, the technical approaches to their generation (including a discussion of host animals and transplant conditions tested), and presented transplantation success (take) rates across groups and across transplantation conditions. At the time, there were just over 500 unique PDX models created by these investigators representing all three clinically defined subtypes (ER
Keywords
Animals, Humans, Female, Breast Neoplasms, Xenograft Model Antitumor Assays, Heterografts, Disease Models, Animal, Translational Research, Biomedical
Published Open-Access
yes
Recommended Citation
Michael T Lewis and Carlos Caldas, "The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer" (2024). Faculty, Staff and Students Publications. 7069.
https://digitalcommons.library.tmc.edu/baylor_docs/7069