Language

English

Publication Date

8-1-2025

Journal

The Lancet Psychiatry

DOI

10.1016/S2215-0366(25)00124-5

PMID

40582370

PMCID

PMC12332855

PubMedCentral® Posted Date

6-26-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from the past half decade of research by this international group of investigators in five priority areas: discovery of common variants using GWAS; rare variation and its interplay with polygenic risk; leveraging genetics to go beyond diagnostic boundaries; ascribing functional attributes to genomic discoveries; and developing and implementing processes for data sharing, outreach to various communities, and training. The insights gained in these domains frame the agenda for the next phase of PGC research. In addition to accelerating integrative common and rare variant-, within- and across-disorder findings for multiple psychiatric and neurodevelopmental conditions, the next phase will leverage multiple populations to further elucidate genetic etiologies, integrate results with rapidly accumulating multi-modal functional genomics data to gain mechanistic understanding, bring genetic findings to clinically actionable phenotypes such as treatment response, and address the emerging use of polygenic scores. Taken together, these next steps will illuminate the biological underpinnings of psychiatric disorders, which continue to contribute to global morbidity and mortality.

Keywords

Humans, Mental Disorders, Genomics, Genome-Wide Association Study, Genetic Predisposition to Disease, Multifactorial Inheritance

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.